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Retinol Complex 0.25

Original price was: $64.00.Current price is: $51.20.

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End of Year Sale · 20% Off · Ends Dec 31

Gentle entry-level 0.25% encapsulated retinol serum designed to renew skin texture and tone with minimal irritation.

 

Processing time: 3-5 business daysYour order is carefully prepared, packed and handed to the carrier within 3-5 business days.

 

Shipping: 4 – 7 business daysOnce dispatched, delivery takes about 3 business days.

 

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Clinically Proven Skincare

SkinMedica Retinol Complex 0.25 is formulated for individuals new to retinol or those with sensitive skin. Micro-encapsulated retinol gently accelerates cell turnover to improve skin texture, tone, and fine lines without excessive dryness.

01

0.25% encapsulated retinol provides a gentle introduction to retinoids

02

Diminishes early signs of aging, fine lines, and blemishes

03

PhytoShield Complex shields skin from free radicals and reduces redness

04

Prepares skin for higher concentrations of retinol

How to Use

Apply a single pump in the evening to clean, dry skin.

Start with 1–2 times weekly and increase frequency as skin adapts.

Always wear sunscreen during daytime.

Skin Type

First-time retinol users and sensitive skin types.

Dermatologist-Tested

Cruelty-Free

Medical-Grade Formulas

Made in the USA

Verified Customer Reviews

What Customers Are Saying

4.7★★★★★out of 5 · average of 217 verified reviews
5 ★176
4 ★32
3 ★5
2 ★3
1 ★1

A representative sample of verified customer reviews for this product, collected from authorized SkinMedica® retailers — not reviews placed on this store. Ratings are shown across the full range, including critical reviews. Individual results may vary.

★★★★★October 01, 2026

Too harsh

This is a very good product however it is to harsh for my skin. In the past I used this 2X a week and did not have a problem. Now even 1X a week is to much

Customer from Florida, Age 70-79Verified Purchase

★★★★★April 12, 2026

Must buy!

I have super sensitive skin but wanted to start a retinal, this is the one!!! Didn’t irritate my skin like most do, must buy!

BRS1989 from North Carolina, Age 30-39Verified Purchase

★★★★★March 22, 2026

Results for Millennial Beginners!

This serum from SkinMedica is a fantastic baby step into retinol, I have been using it nightly with any negative reactions (my first foray was 0.5 serum and it took a week for my skin to recover). I started by sandwiching the retinol between layers of moisturizer was helpful, but I’ve found I can now tolerate it well as a base layer and alongside my eye cream; for newbies, fear not! This product smells lovely and so easy to apply evenly, and is a great product for retinol newbies like me!

AutumnWinters from Massachusetts, Age 40-49Verified Purchase

★★★★★March 02, 2026

Sensitive skin

this product dried my skin something awful. Don't recommend it

LMBROWN65 from Minnesota, Age 60-69Verified Purchase

★★★★★February 24, 2026

Good News For Sensitive Skin

I can't use many skin products as they're too harsh. I'm aging as I write this so I was desperate to find something to use to exfoliate and fight against wrinkles. I'm glad to report the 0.25 is gentle. My plan is to move up to 0.5 with hopefully no problems

Lyndaaa from Pennsylvania, Age 60-69Verified Purchase

★★★★★February 10, 2026

Good for sensitive skin

This is the first time I’ve used Skinmedica retinol. I’ve been using another brand for sensitive skin and wanted to try a less expensive option. I’ve had no redness or excessive dryness. It seems to be working for smoothness and even tone

Customer from South Carolina, Age 70-79Verified Purchase

★★★★★January 21, 2026

Mild Retinol

I've using the .50 and it was getting a little too much. I am now using .25 and less irritation and less serious flaking so I can use it more often

DVSKIER from Arizona, Age 70-79Verified Purchase

★★★★★January 09, 2026

ABSOLUTELY LOVEEE

This is by FAR AMAZING! I am very picky with my skin products, and I was absolutely blown away with this. I apply this after my.Alastin gentle cleanser, and then I will put my SkinMedica ceramide moisturizer and unbelievable results the next morning after the first week you can really see good results but the first time I use this I seen results the next morning I was blown away

Customer from New Hampshire, Age 40-49Verified Purchase

★★★★★December 31, 2025

Love

My fav retinol in a lower percentage for my sensitive skin to tolerate

lanskincare from FloridaVerified Purchase

★★★★★December 02, 2025

Effective Retinol for Sensitive Skin!

I love how gentle yet effective this retinol is. It helps with fine lines, uneven skin tone, and overall skin texture. I noticed improvements within a month and my skin feels soft, smooth, and radiant

Customer from IllinoisVerified Purchase

★★★★★November 22, 2025

Just strong enough!

At my age (71) I know retinol should be a part of my skin care regimen. This product gives me a healthy dose of retinol without the side effects of a stronger formula with more retinol. Any product above 25% retinol turns my skin red and flaky. This does not. It goes on like a lotion and even feels moisturizing!

Grandmama from Florida, Age 70-79Verified Purchase

★★★★★November 08, 2025

Literally. I have never used a retinol product before, so I wanted to start out with the lowest formula and work my way up. I have been using it every other night with SkinMedica’s TNS Advanced Serum. I think it is the perfect combination of products. I didn’t want to worry about redness and peeling which I have heard can occur whenever using a retinol product. I am on my second bottle of retinol now and I think I will be using this religiously forever. I have a friend who uses this product and has been for years and she suggested it to me. If her skin is any example, I will be using this forever

KonaSunshine from Hawaii, Age 70-79Verified Purchase

★★★★★October 22, 2025

Good option for starting on retinol

Starting on retinol can be very drying and this is a good starting point for your skin to gain tolerance

Customer from Iowa, Age 50-59Verified Purchase

★★★★★August 08, 2025

Good

So far so good. It will take time to see if there are results, but I like that it doesn’t have a strong fragrance and I have had no adverse skin reactions

Customer from Oregon, Age 60-69Verified Purchase

★★★★★July 20, 2024

Nothing to report

I've been using this for a few weeks now, and I cannot say I have noticed any difference. In one way, that's good because my sensitive skin hasn't had a reaction to it. On the other hand, my skin looks dull and a little dryer. I definitely will not be repurchasing it

NoniVerified Purchase

★★★★★June 03, 2024

Easy on the skin!

I peel very easily with retinol so going back down to the lower percentage has been working great!

KelliSmithRunyonVerified Purchase

★★★★★April 23, 2024

Good retinol for starters

I used up a bottle of this retinol before moving to something stronger. Not sure if it gave me good results but didn’t break me out or irritated my skin. Good if you want something more mild or have sensitive skin

CustomerVerified Purchase

★★★★★January 12, 2024

Not for me

To be fair to skinmedica, I just don't think I can tolerate retinol, even attempting 1x a week at this low dose. I get breakouts and weird sores. Just irritates, even if I buffer it with some HAT or replenish. Really bummed about it so using it on my inner arms and belly area lol. Certainly don't want to waste it! I have extremely sensitive facial skin

CustomerVerified Purchase

★★★★★October 13, 2023

SkinMedica Retinol Complex 0.25

Just started using this product, it makes me a little itchy. Still using it, because it seems to be helping my fine lines

DDHVerified Purchase

★★★★★July 20, 2023

Retinol with ease

SkinMedica's .25 has been an easy reintroduction after going off any type of complex for at least 6 months. I was apprehensive because it had been a short time since a severe sensitive skin reaction to another brand's product, but this was used without any problems. My skin is super reactive to various ingredients, especially fragrance, but SM causes zero problems. Will move up to .5 next go round

CustomerVerified Purchase

★★★★★April 06, 2023

Great product

I use this once a week. I really like it so far

MANVerified Purchase

Additional information

Size

30 ml / 1 fl. oz. U.S.

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