Sale!

Retinol Complex 0.5

Original price was: $80.00.Current price is: $64.00.

-20%
End of Year Sale · 20% Off · Ends Dec 31

Medium-strength encapsulated 0.5% retinol serum that enhances cellular turnover, smooths wrinkles, and refines texture.

 

Processing time: 3-5 business daysYour order is carefully prepared, packed and handed to the carrier within 3-5 business days.

 

Shipping: 4 – 7 business daysOnce dispatched, delivery takes about 3 business days.

 

Secure checkoutAll payments are encrypted and fully protected.

Clinically Proven Skincare

SkinMedica Retinol Complex 0.5 renews skin and diminishes the appearance of fine lines, wrinkles, and uneven tone. Features a micro-encapsulated PhytoTriene system that delivers controlled release for maximum efficacy with minimized irritation.

01

0.5% pure encapsulated retinol enhances skin renewal

02

Smooths fine lines, deep wrinkles, and rough texture

03

Antioxidant PhytoShield Complex protects skin barrier and calms redness

04

Enhances skin radiance and elasticity

How to Use

Apply a single pump in the evening to clean face.

Begin by using 1–2 times per week, gradually increasing frequency as tolerated.

Use daily broad-spectrum SPF 30+ sunscreen during daytime.

Skin Type

Ideal for skin pre-conditioned to retinol or looking for moderate anti-aging correction.

Dermatologist-Tested

Cruelty-Free

Medical-Grade Formulas

Made in the USA

Verified Customer Reviews

What Customers Are Saying

4.8★★★★★out of 5 · average of 351 verified reviews
5 ★290
4 ★42
3 ★13
2 ★5
1 ★1

A representative sample of verified customer reviews for this product, collected from authorized SkinMedica® retailers — not reviews placed on this store. Ratings are shown across the full range, including critical reviews. Individual results may vary.

★★★★★October 17, 2026

Retinol Cream

I enjoy this retinol cream. It has a smooth and creamy texture. I have sensitive skin, but it has not irritated or dried out my skin. Will purchase again

MarshaG from Kentucky, Age 50-59Verified Purchase

★★★★★October 11, 2026

So far, so good

My skin is very sensitive so I can only use .5 retinol every other day. I use a lot of SkinMedica products…this one hasn’t disappointed. I cannot say much about results b/c I just started using it but I’m sure it will be great as all their products I’ve used have kept my skin looking good

Alinnis03 from Ohio, Age 40-49Verified Purchase

★★★★★October 03, 2026

SkinMedica Retinol Complex 0.5

This is the best retinol. i have been using it for a few years and can't go without it

BethB from Florida, Age 60-69Verified Purchase

★★★★★September 18, 2026

Good!

Honestly, I didn't stick with using this product, even though it is top-tier among all retinol products. It makes my skin peel, which I don't like. Maybe the 0.5 strength is too strong for me

Customer from CaliforniaVerified Purchase

★★★★★August 25, 2026

Great retinol product

I have been using this product in .25 strength for years and wanted to try the .50. I am using it every other day with a moisturizer underneath and it’s working beautifully! I will slowly attempt more days per week

Customer from Arizona, Age 60-69Verified Purchase

★★★★★August 10, 2026

sensitive skin

I have sensitive skin and I had stopped using retinol products because they cause so much irritation on my face. This one does not have that effect. It's not irritating, seems to be moisturizing and I like how my skin looks using it. I'm 70 and my skin is fair

Stacia from Arkansas, Age 70-79Verified Purchase

★★★★★July 13, 2026

I used it every night!

I started off with this .5 overnight for 6 months. I really noticed a difference in my texture and fine lines so I moved to the 1.0. Now I use the 1.0 most nights, but when I start flaking (usually in the summer) I go back down to this .5. Great to have both strengths on hand depending if I have been in the sun or not. Can't go wrong with skin medica!!

simsim from California, Age 60-69Verified Purchase

★★★★★July 07, 2026

Retinol must

This is the gold standard in retinol. It doesnt dry your skin out like some brands. Great for keeping skin looking youthful

Customer from ArizonaVerified Purchase

★★★★★July 07, 2026

Great, nn-irritating retinol

I've been using this for a few years now, applying to my skin about 3 times a week, in the evenings. Couple with a red light mask, my skin looks rejuvenated!

CustomerVerified Purchase

★★★★★June 27, 2026

SkinMedica Retinol Complex 0.5

My dermatologist recommended I try SkinMedica Retinol Complex 0.5 and i have to say I am very happy with the results I have seen so far after just several weeks. My eye doctor even noticed and asked me what I was using on my skin. I would definitely recommend it and buying from was a very pleasant experience all around

ssmh from FloridaVerified Purchase

★★★★★June 03, 2026

Great

This is my first re-introduction to retin A. I am starting off slow and this retinol complex hits the mark

Customer from South Carolina, Age 60-69Verified Purchase

★★★★★June 01, 2026

Game Changer

This is a must in your cart if you’re over 50! It has given my skin a smoother look, shrinks pores and reduces wrinkles

Customer from Minnesota, Age 50-59Verified Purchase

★★★★★May 30, 2026

Tried and True

Excellent, gentle retinol for daily use. Delivers results in a fast yet gentle way. Cannot go wrong with this nightly product!

CaroleAllen from North CarolinaVerified Purchase

★★★★★August 01, 2025

So far so good

I ordered this because I ran out of my Rx Tretinoin. I went with the 0.5 because I previously used the .1 and it irritated my skin. So far good..I've only been using for about 2 weeks but no dryness or irritation. It does burn slightly but it dissipates quickly. I use several Skin Medica products

AmyJ from Texas, Age 60-69Verified Purchase

★★★★★June 03, 2025

Next step up retinol

This is the next step up for me from the .25, which I've used for quite a while without any dryness or flaking. I have sensitive skin so I am always reluctant to use too strong of a product. I tried it full strength, in a small amount, and did get some minor flaking around my chin, nothing terrible. Trying to apply every other night or twice a week if I feel it's too strong. I also tried mixing some of the .25 with the .5 thinking it is a bridge between the two as I get acclimated to it. It is a great retinol though, not greasy, gel-like, sinks right in and dries down fast. I am putting on my HA5 hydra collagen after it. So far so good…slow going

CustomerVerified Purchase

★★★★★April 26, 2025

Not sure

I'm just not sure this is worth it. It seems as though you need to use a lot to cover your face and it says one pump. I think for the price, there's nicer products out there

CustomerVerified Purchase

★★★★★September 30, 2024

Must have

Noticeable difference after using this product. I’ve been able to use it every other day and no burning or other affects

CustomerVerified Purchase

★★★★★January 12, 2024

very potent and harsh

I have used prescription stuff before and even that had not caused the irritation I experienced with this product. I am surprised at the level of redness, peeling and raised spots I got none of which do not want to calm down for some reason- even though I stopped and have been moisturizing intensely. I am lucky if my skin tolerates this once a week

CustomerVerified Purchase

★★★★★December 23, 2023

Just ok

This product is just OK. It doesn't keep my skin as vibrant, clear, and bright as other 0.5 retinol products. I'm going back to another brand

CustomerVerified Purchase

★★★★★July 11, 2023

Can only use very little, major skin irritant

This caused retinol burn after just a few uses. I had to stop applying everything except a healing moisturizer after using it until my skin healed–I have never had such a strong reaction. After healing, I have tried working it into my nightly routine once a week and that has not caused the same issue

MattieMae29Verified Purchase

★★★★★March 07, 2023

Still on the fence

I’m not sure if I will continue to use this product as after one application it made my face dry and irritated. I will maybe use once a week to build up a tolerance

Jlm45Verified Purchase

★★★★★June 25, 2022

No product consistency

I’ve purchased 2 bottles. The product in the first bottle was a tan color. It did nothing. I had no skin peeling. No skin improvement. The product in the most recent second bottle was very white & my skin peeled quite a bit. I can only guess that the first bottle was defective. Upsetting since I spent so much money on it. I’m still using the second bottle. Hoping for some improvement in brown spots, but no difference yet. So, overall, I’m not sure what to think or if I’d risk ordering again

bb47Verified Purchase

Additional information

Size

30 ml / 1 fl. oz. U.S.

Customer Reviews

5.0
out of 5 stars
0 verified ratings
5 ★
0%
4 ★
0%
3 ★
0%
2 ★
0%
1 ★
0%

No customer reviews yet. Be the first to review!