Clinically Proven Skincare
This next-generation, skin rejuvenating formula improves the appearance of coarse wrinkles, fine lines, skin tone, and texture. It’s the only growth factor product proven to address sagging skin. Visible results in just 2 weeks. Results continue to improve through 24 weeks of use.
01
Clinically proven to smooth the appearance of coarse wrinkles and fine lines
02
Only growth factor formula proven to address sagging skin
03
Improves feeling of skin firmness and elasticity
04
Visible results starting in just 2 weeks with progressive improvement up to 24 weeks
05
Colorless, fragrance-free, lightweight with a matte finish
How to Use
Apply in the morning and evening after cleansing and toning.
Dispense one pump from each chamber onto the back of your hand, blend together, and apply evenly across face, neck, and chest.
Skin Type
Appropriate for all skin types.
Dermatologist-Tested
Cruelty-Free
Medical-Grade Formulas
Made in the USA
Verified Customer Reviews
What Customers Are Saying
A representative sample of verified customer reviews for this product, collected from authorized SkinMedica® retailers — not reviews placed on this store. Ratings are shown across the full range, including critical reviews. Individual results may vary.
Definitely smoother skin
I have only been using this for a little over two weeks and I can definitely tell a difference in the appearance of my skin. My skin looks and feels smoother and brighter. I can't wait to see the difference after using it long term
Customer from Missouri, Age 40-49Verified Purchase
A Skincare Staple Worth the Investment!
SkinMedica TNS Advanced+ Serum has become one of my favorite skincare products. I love how it makes my skin feel smoother, firmer, and more hydrated. It’s lightweight, absorbs beautifully, and layers well with my other skincare products. I appreciate a product that focuses on improving skin quality rather than just providing a temporary glow. Although it’s pricey, I feel it’s a worthwhile investment in maintaining healthy, youthful-looking skin. Definitely a staple in my skincare routine
Customer from Tennessee, Age 50-59Verified Purchase
Luxury in feel and easy to use day and night
I just started using this and already feel like it is a winner!
Customer from Minnesota, Age 70-79Verified Purchase
5 stars in waiting?
I haven’t used this too long but am liking A LOT what I am seeing. It seems to have softened lines and skin clearer. It is frightfully expensive so it will need to definitely become 5 star worthy if I purchase again but so far so good!
Daphne1 from California, Age 70-79Verified Purchase
The Gold Standard in Skin Care
I never want to run out of this product!!!!
Customer from Tennessee, Age 60-69Verified Purchase
Good product
I like this product a lot, but I'm not sure how much difference it makes for the price. I only purchase it when it's on sale, and I want to try one more round, but the cost for the amount is a lot. It didn't seem to last very long, and I only used it once a day
CustomerVerified Purchase
Amazing product!
I’ve been using for 2 years already & it’s one of my favorite products for anti-aging! Big fan of skin medica…highly recommended!
Customer from Florida, Age 30-39Verified Purchase
A Fan For Life!
What I love most about SkinMedica’s TNS Advanced+ Serum on a daily basis is how immediately satisfying it is to use. The texture is lightweight, absorbs effortlessly, and layers beautifully under my other products. From the very first week, it has kept my skin feeling incredibly soft, touchably smooth, and deeply hydrated. It gives my complexion that coveted plump, healthy, dewy look that makes me feel like I just stepped out of a high-end medical spa. For anyone hesitant about the investment, take it from someone who uses it religiously: it works. It doesn't just rest on top of your skin; it completely transforms your texture from the inside out. If you want a product that backs up its claims with actual visible smoothness and firmness, this is it. SkinMedica has a fan for life!
btdt2 from Missouri, Age 60-69Verified Purchase
Soft, glowing skin
Love this serum! TNS Advanced+ has quickly become one of my favorite skincare products. My skin feels smoother, firmer, and more hydrated, and I’ve noticed an overall improvement in its texture and appearance. It’s definitely an investment, but a little goes a long way and I feel like I’m actually seeing results. Worth the splurge!
Customer from Illinois, Age 50-59Verified Purchase
The Best
I've been using TNS 2x daily, including on my neck, for about 8 weeks. The softening of fine lines (and even deeper ones) is noticeable. I also use Skinmedica's Instant Bright Eye Cream. I finally ordered the Neck Correct Cream and will start using that for more focused treatment there, but TNS is a permanent part of my skincare routine
Customer from Oregon, Age 50-59Verified Purchase
Seems to be working well
This seems to be helping the texture of my skin. I'm noticing less fine lines and crepiness. Only negative is that one side of the formula often seems to run out more quickly than the other even though I use equal amounts each time
Megg from Texas, Age 50-59Verified Purchase
Favorite skin care
Makes your skin feel great
Customer from NebraskaVerified Purchase
Love!
I would bathe in this serum if I could. I have used it for over 12 years and love how my face feels and looks
Customer from IllinoisVerified Purchase
The high reviews are accurate
I gave TNS advanced+ serum a try based on an Allure magazine review. It is an amazing product. It has diminished fine lines and wrinkles around my eyes and lips and has given my skin a healthy glow. I acknowledge that it is costly. I'll continue to buy it as long as the formula doesn't change and the cost doesn't increase
Customer from Iowa, Age 40-49Verified Purchase
Great serum
I like this serum very much. I’m on my third order. It makes my skin very smooth and really does help fine lines and wrinkles. I plan to continue using this serum and highly recommend it
CC11 from ArizonaVerified Purchase
Nothing better
I have been using this for years even before the package change. I tried cheaper products and some near the same cost but I keep coming back to this. It works for me. My lines are less noticeable and skin tone brighter when this is my product
BTrapp from Louisiana, Age 70-79Verified Purchase
Dried my skin out
Dried my skin barrier will discontinue use amd stick with recovery i perfer recovery over advance
Crystalm Age 40-49Verified Purchase
Not sure if worth the $$$
I bought this serum two times so far and one bottle has lasted me about 1.5 months if used 1x a day. It is very expensive and I am not sure if it is worth the price. Haven’t noticed any major difference in skin texture or fine lines. I believe there are other products that don’t cost as much that can produce the same or better. I will try something else out
Customer from Florida, Age 30-39Verified Purchase
SkinMedica TNS
I've only been using this product for three weeks, but up until now, I have not seen any improvement in my lines and wrinkles. I hoping with more time I will see some positive results
Customer from CaliforniaVerified Purchase
Not Impressed
I have been using it for 7 weeks and haven't noticed any improvements in my skin, not even the texture. When I run out of this bottle, I won't be buying another one
Customer from Florida, Age 50-59Verified Purchase
Not happy with the new pump!
I’m 49 and have used TNS serum many years but my last 2 bottles the peptide side ran out way before the other and that makes the product not effective. I’m going to need to look at buying other products because I can’t afford for my product to run out like that
HollyS1 from Texas, Age 40-49Verified Purchase
One Side Ran Out Before the Other!
I love the TNS Advanced+Serum. I've been using it for about a year now. Never had an issue with the two sides regarding distribution but this bottle (which is the new version) has been completely empty with the clear Serum for a week now! This is way too expensive for this to be happening
Customer from Arizona, Age 60-69Verified Purchase
