Clinically Proven Skincare
SkinMedica HA⁵® Hydra Collagen Hydrator provides immediate and long-lasting 48-hour continuous hydration. Formulated with double the concentration of hyaluronic acid, vegan hydra collagen, and advanced VITISENSCE® technology, this fast-absorbing formula smooths the appearance of fine lines and wrinkles while replenishing the skin’s moisture barrier.
01
Instant smoothing and visible plumping of fine lines and rough texture
02
Provides continuous, deep hydration for up to 48 hours
03
Features 5 distinct forms of Hyaluronic Acid with varying molecular weights
04
Formulated with Vegan Hydra Collagen to support natural elasticity
05
Lightweight, non-greasy, and absorbs seamlessly without pilling
How to Use
Apply twice daily, morning and evening, after cleansing and applying treatment serums.
Dispense 1 to 2 pumps onto fingertips and gently massage over face, neck, and décolleté.
Skin Type
Suitable for all skin types, including dry and sensitive skin.
Dermatologist-Tested
Cruelty-Free
Medical-Grade Formulas
Made in the USA
Verified Customer Reviews
What Customers Are Saying
A representative sample of verified customer reviews for this product, collected from authorized SkinMedica® retailers — not reviews placed on this store. Ratings are shown across the full range, including critical reviews. Individual results may vary.
new packaging dreadful!
I have been a BIG fan of HA5 for several years. I've never written a negative review but here goes. The new package contains 1.7oz instead of 2oz, the bottle is a LOT heavier, so tall is no longer fits in any cabinet in our bathroom. AND the price has gone up. A BUST of a rebrand! Very sorry to say Skin Medica, I am no longer a fan
Customer from Washington, Age 70-79Verified Purchase
Heavenly
I'm a huge SkinMedica fan and this one of my all-time favorite products. It adds significant hydration to dry skin without leaving it greasy or overly dewy. It layers well under sunscreen and makeup, and unlike many serums, it does not pill. I apply it twice a day, followed by a light mist of mineral spray. It has been a great way to help my skin repair from the dryness and patchiness caused by daily Retin-A use. The bottle lasts several weeks with twice daily use, but it's still very expensive. Makes a great gift!
Customer from CaliforniaVerified Purchase
Great Product
I have never been able to use a retinol product. My skin is very sensitive and becomes very red and irritated. This product is the exception. I started out slowly and while I did become slightly irritated, it was manageable. I slowly worked up to every other night and sometimes nightly. No more irritation and my skin looked great. I could really see a difference in my skin. I used to whole bottle and I'm now trying to use the stronger .50. I will review that after a few weeks
Customer from Arizona, Age 60-69Verified Purchase
Great stuff!
I love this! Contributes to better looking skin
IloveMainecoons from Massachusetts, Age 70-79Verified Purchase
Dewy face
I am 60 and have used skinmedica for 25 years. I use TNS, retinol and finish the night time routine with this. Wake up to less wrinkles and dewy skin in am. Expensive but you do get plumping results
Customer from FloridaVerified Purchase
SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator
SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator is one product that I refuse to do without. I have been using this product through it's evolution for years…starting with the SkinMedica HA5. They have changed packaging and have updated the formula and it's still one of the best products for helping my skin hold onto much needed moisture. I use it twice daily and people are always asking me…"What is your secret?"!!!
MeowserKat from Louisiana, Age 80+Verified Purchase
Skin Medica HA5
This Skin Medica HA5 Hydra Collagen Replenish and Restore is my new favorite product. Goes on smooth not heavy at al! It hydrates and leaves my skin glowing. I use morning and nite. With and without any other products first. Highly recommend this product
Customer from California, Age 60-69Verified Purchase
Plumps and hydrates skin
I have been using HA5 Hydra Collagen twice daily for a few years. I have noticed my skin feels more hydrated, plump and youthful. I use it after TNS Advanced Serum in my daily skin routine. These two are a dynamic duo in keeping my skin looking and feeling great
Customer from WashingtonVerified Purchase
JCAP
Honestly, what happened to this formula??? I loved it before. NOW IT SMELLS TERIIBLE! What is the deal with that???
Jcap from MarylandVerified Purchase
Very hydrating!
Very hydrating and looks works well under makeup
Sharon0614 Age 50-59Verified Purchase
My skin needed this!
Little did I realize This added step in my skin care routine was much needed… Just a little product goes a long way. My reason for not giving 5 stars is the new packaging…I saw other reviewers comment on the new glass container. My issue is it is @1/4” too tall to fit into my newly installed mirrored medicine cabinet shelf (my other products (Revision) fit just fine… and I want to make sure I don’t knock it over on my countertop given the cost
ELS from South Dakota, Age 70-79Verified Purchase
Great moisturizer
Really soothing and calming on skin. Feels very moisturizing. Lasts all day and night. Highly recommend!
Customer from CaliforniaVerified Purchase
Less product AND more money
I hate it when companies do this. So sorry to have to say goodbye to this because it does work. It was already very expensive. I was just going to buy again but can’t justify at the even higher price for less product. Reviews say it not even the same stuff. Very disappointed
CustomerVerified Purchase
Silky Smooth Skin
I’m on my second bottle of the Skinmedica Ha5 Hydra Collagen serum. I pair it with the Skinmedica TNS serum and they layer well together, and with makeup. The Ha5 serum goes on silky and absorbs well, dries well, and feels amazing. This was the first Skinmedica product I tried and I was sold on it immediately. I’ve been able to purchase it on sale both times for a great price!
Customer from New York, Age 50-59Verified Purchase
Skin Medica Makes Excellent Medical Grade Products
You truly get your money's worth with everything I have tried from Skin Medica. I was first gifted the product by my sister. Then I said, "I'm worth it." A tiny bit goes a long way! It hydrates and plumps my skin, giving me all day hydration and comfort, and I believe it imparts skin nurturing ingredients. My face would feel deprived if I did not smooth it in each morning and evening. remembers me with both ads about what I have ordered as well as little rewards or points for what I purchase. I watch for specials to re-order. One mention: This product used to be packaged in a lighter container. As of my most recent order, they have changed to glass. If you are clumsy with wet hands beware! While the glass may be better for the life of the product, try NOT to knock over!
Doesherhomework from California, Age 70-79Verified Purchase
New HA5 Hydra Collagen Replenish + Restore Hydrator packaging
The new packaging for the HA5 Hydra Collagen Replenish + Restore Hydrator is pretty but awful! It's only 1.7 ounces while the older one was 2 ounces! Additionally, I have to take it apart and shake the remaining serum out of the bottle after using about 1 ounce of the product! I have used this serum for years but I refuse any longer to pay more for less product in a container that doesn't pump out all of the product!! Help SkinMedica!!
Maui4Me from Arizona, Age 70-79Verified Purchase
Less product for same price
I prefer the blue bottle over the new look which is heavier with less product yet same price. In addition, it doesn’t feel on my skin as the same as the product in the older packaging. Looking to switch to a different brand. Disappointed as this used to be one of my favorites but can’t justify the price
Customer from NebraskaVerified Purchase
Great hydration. Formula change?
After receiving samples from my dermatologist and liking the product I decided to purchase the product. It seems like in addition to a package change the formula changed as well. The new formula and consistency seems lighter than the previous formula. Overall I like the product and it gives my face a nice glow. I would have preferred the previous formula/product
Customer from Connecticut, Age 40-49Verified Purchase
Love this hydrator
I’ve been using this for years either in the morning or evening before bed in the winter months. It’s a great source of moisture without being super heavy and greasy
Koliver from Nebraska, Age 40-49Verified Purchase
Too early to tell
I just started using this product so I’m not sure how I feel about it yet. No immediate visible results. My skin doesn’t feel as soft and moisturized as with other products I have tried with similar ingredients so I’m not sure if I will buy again. It’s expensive and others seem to work as well for less money?
AuntieKO from California, Age 60-69Verified Purchase
Bring back the old!
This new formula is not it. I had the previous version on subscription for years. Worked beautifully!! This is thin and my face does not feel hydrated. Makes it difficult to apply my foundation. The worst part is the smell, it smells like it went bad! I'm about to throw it out and move on to another brand. Please bring back the old version Skinmedica!
Customer from Iowa, Age 40-49Verified Purchase
Nice moisturizer
Love the moisturizer effect of this product. I put it on top of day and nighttime serums or treatments. Have been using product for 3 week. Seem to "soften" fine lines. The moisture seems to last all day on me, but not heavy or oily. Might consider keeping this one in my skincare routine. No break outs or irritation
FlygirlD from ArkansasVerified Purchase
Silky Smooth
I love how smooth and silky the product feels on my skin. Non-irritating on my neck and decollete
GANurse from Georgia, Age 50-59Verified Purchase







